Searchable abstracts of presentations at key conferences on calcified tissues

ba0005p415 | Osteoporosis: treatment | ECTS2016

rs72658163, a new heterozygous variant in COL1A2 associated with atypical femoral fracture

Funck-Brentano Thomas , Ostertag Agnes , Debiais Francoise , Fardellone Patrice , Collet Corinne , Mornet Etienne , Cohen-Solal Martine

Atypical femoral fractures (AFF) of the subtrochanteric region are rare. Bisphosphonates account to a large extent to their occurrence, however AFF also occur without exposure to bone medication. We here assessed the genetic factors associated with AFF among subtrochanteric fractures. Cases of subtrochanteric or femoral shaft fractures were identified through ICD-10 codes in three French academic centers from 2007 to 2010. Medical records were analyzed by two investigators tha...